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I highly recommend O Chardinet!! I hope to visit again someday. From the spacious room we got pictured to the exquisite views, the remote and lovely landscape, the close proximity to Ainsa, but mostly the warmth of our hosts were so appreciated.

Ferran cooks dinner each night if requested and breakfast is provided. Mireia's home made jams and all the locally sourced foods were perfect. We also appreciated the remodel of the ancient home, complete with radiant heat flooring, using their own bio mass to heat the house, their rambling garden, everything "green" to make it feel ultra modern but with the feel of something old.

We will be back if we can!

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This is an ideal spot to explore some of the parks of the region. Charo is a picturesque village overlooking Huesca Province and is very quiet. Locating ourselves in Charo gave us the opportunity to enjoy a large area of the great outdoors.

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We were able to do a fantastic via ferrata named Feradada del Toscar nearby as well as canyoning. The room was very clean and really nice. The two are a great hosts and provide great conversation whilst making you feel very welcome.

This was the best place we stayed on our 2 week holiday and is very, very highly recommended. Thank you Mireia and Ferran ChrisT The drive is beautiful and close to national parks and local hikes.

The room was modern, clean, and comfortable. The included breakfast and paid dinner were tasty and regional.

Guirnalda de Otoño.

Medical Source text - Portuguese Objetivo. Translation - Spanish Objetivo. Clinical Study General field: The trial consisted of a single dose and a multiple dose parts including extension, where dosages of 0. Fifteen patients were enrolled in the single dose part and 24 patients were enrolled in the multiple dose part.

A total of 28 patients completed the trial, 15 patients completed the single dose part and 24 patients completed the multiple dose part.

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Eleven patients participated in both, the single and multiple dose parts. Fifteen patients finished the first 6 treatment weeks according to the protocol. Of them, 8 patients showed stable disease after 6 weeks, 6 of them continued the treatment for further 6 weeks. Four of these patients remained stable after 3 months.

Serum concentrations of MGN after single and multiple doses were variable, but could be determined in most patients who received doses higher than 0.

After both single and multiple dosing AUC and Cmax increased with dose, however not in a dose proportional manner.

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No accumulation was observed after multiple dosing. Single and multiple dose s. After single dose administration of MGN 12 out of 15 patients experienced at least 1 treatment emergent adverse event.